December 24, 2009| December 24, 2009 |
Science Division | Back to Chemistry |
SPRING 2010
Physical Biochemistry (P. Chem. II, aka CHEM33500)
INSTRUCTOR
: Prof. Sacha De Carlo (x6070)
sdecarlo[at]ccny.cuny.edu
Classes
: Tue, Thu 9:30-10:45 AM, room MR-1307
Recitation/Q&A: Tue 11:00-11:50 AM, room MR-1307
Lab : Tue/Thu 2-6 PM
Office Hours : Thursday 11:00-11:55 AM
ANNOUNCEMENTS
The syllabus is available, please find it here.
The labs are supervised by instructors:
Aswin Natarajan (Ghose lab - room 1324) and Yi He (Lazaridis Lab - room 1325).
General policies
1) It is your responsibility to be aware of all announcements that may be made in class during this
semester. If warranted by circumstances, the instructor may modify course policies during the semester.
2) Cell phones must be turned off during class.
3) Palm-size, laptop or other portable computing devices (including iPhones and similar) are not permitted during tests or the final.
4) All tests/quizzes/midterms and the final are closed book and no notes.
5) Please do not drop-in outside designated office hours without an appointment. E-mail is the preferred mode of contact.
Textbooks
Tinoco et. al. Physical Chemistry, Principles and Applications in Biological Sciences, 4th ed. © 2002 Prentice Hall
van Holde et. al. Principles of Physical Biochemistry, 2nd ed. © 2008 Prentice Hall
Atkins & de Paula. Elements of Physical Chemistry, 5th ed. © 2009 Freeman and Co.
The texts are not mandatory and all lecture notes/materials will be posted on this page.
Grading
Grades will be based on tests (best 2 of 3 - 15%), lab (15%), mid-term (35%) and final (35%).
Schedule (tentative)
1/28 2/2; 2/4 Biological Macromolecules, Structure 2/9 Statistical Thermodynamics, Principles 2/11 Chemical reactions and chemical potentials 2/16; 2/18 Kinetics Principles, Enzymes 2/23 Test 1 2/25 Molecular motion, Diffusion 3/2 Sedimentation, Viscosity and Electrophoresis 3/4; 3/9 Intro on Wave Mechanics 3/11 Test 2 3/16 Absorption and Emission Spectroscopy 3/18
Linear and Circular Dichroism 3/23 Scattering from Solutions of Macromolecules I 3/25 Midterm 3/30 Spring Break 4/6; 4/8 Fourier Transform and X-Ray diffraction, CAT 4/13; 4/15 Nuclear Magnetic Resonance Spectroscopy 4/20 Magnetic Resonance Imaging 4/22 Positron Emission Tomography 4/27 Test 3 4/29; 5/4 Cryo-electron microscopy and 3D image reconstruction 5/6 Visualization software and bioinformatics 5/11 No class (prof at the GC) 5/13 Review before final 5/18 Final
Review dates ; mid-term on March 30th
Final Exam date set to May 15-20 by the registrar.
Lecture 1 - General Introduction Lecture 2 - Biological macromolecules Lecture 3 - Thermodynamics
Lecture 4 - Chemical reactions and potentials Lecture 5 - Reaction kinetics Lecture 6 - Enzyme kinetics Lecture 7 - Molecular motion, Fick's laws Lecture 8 - Sedimentation, Viscosity and Electrophoresis Lecture 9 - Intro on Wave Mechanics Lecture 10 - Absorption and emission spectroscopy Lecture 11 - Linear and circular dichroism Lecture 12 - Scattering from solution of macromolecules Lecture 13 - The Fourier Transform and X-ray diffraction Lecture 14 - Nuclear magnetic resonance spectroscopy Lecture 14b - Magnetic resonance Imaging supplement
BCIM 770 - Lecture on X-Ray Crystallography
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